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Sphingosine Kinase 2 (Sphk2) catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P), an important signaling molecule with intra- and. Sphingosine kinase (SphK) mediates the conversion of sphingosine to sphingosinephosphate, a key sphingolipid signaling molecule involved in cell growth. Sphingosine kinases are cytosolic or membrane-associated enzymes that catalyze the phosphorylation of sphingosine to sphingosinephosphate (S1P).

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Sphingosine kinases are the key enzymes that produce intracellular S1P. Here we report that sphingosine kinase 2 (Sphk2) is the major messenger RNA species. Sphingosine kinase (SphK) mediates the conversion of sphingosine to sphingosinephosphate, a key sphingolipid signaling molecule involved in cell growth. Sphingosine kinases possess an intrinsic catalytic activity that is independent on posttranslational modifications thereby generating basal levels of S1P in.

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Sphingosine kinase (SK) 1 catalyzes the formation of the bioactive lipid sphingosine 1-phosphate, and has been implicated in several biological processes in. Sphingosine kinase (SphK) is a conserved lipid kinase that catalyzes formation sphingosinephosphate (S1P) from the precursor sphingolipid sphingosine. Sphingosine kinase isoforms, SPHK 1 and SPHK 2, catalyze the phosphorylation of sphingosine to sphingosinephosphate (S1P). S1P exhibits a broad spectrum.